Instructions
for use

NAD+

Nicotinamide adenine dinucleotide

Pharmacological properties

NAD+ (Nicotinamide adenine dinucleotide) 500 mg / 2.5 ml
NAD+ is a coenzyme involved in the mitochondrial electron transport chain, improves energy metabolism, has an antioxidant effect, and can positively influence cognitive functions, physical endurance, and reduce symptoms of chronic fatigue. Benefits: increases NAD+ levels in cells, providing a rapid energy effect and antioxidant support.

Composition

1 vial (2.5 ml) contains:

NAD+ – 500 mg

Water for injection

PH 6,8–7,0

Indications for use

Chronic fatigue syndrome

Asthenic conditions after acute and chronic illnesses

Neurodegenerative diseases (as an adjunctive therapy)

Support during increased physical and psycho-emotional stress

Antioxidant support.

Contraindications

Hypersensitivity to NAD+ or excipients;

Pregnancy and lactation (due to insufficient clinical data)

Children under 18 years (without clinical recommendations)

Biological Functions of NAD+

NAD+ (nicotinamide adenine dinucleotide) performs critically important functions in human cell metabolism. The main biological functions of this coenzyme are listed below:

NAD+ converts nutrients into cellular energy (ATP):
NAD+ participates in the Krebs cycle and the electron transport chain, ensuring the production of energy in the form of adenosine triphosphate (ATP).

NAD+ activates longevity proteins (SIRT1–SIRT7):
NAD+ is a cofactor for sirtuins — proteins that regulate aging, inflammation, and metabolism.

NAD+ repairs DNA via PARP enzymes:
NAD+ activates poly(ADP-ribose) polymerase enzymes, which repair damaged DNA.

NAD+ reduces inflammatory processes:
NAD+ modulates immune response signaling pathways, lowering chronic inflammation levels.

NAD+ is a neuroprotector and supports cognitive functions:
NAD+ helps maintain mitochondrial function in neurons, which improves memory and concentration.

Method of administration and dosage

Subcutaneously, with an insulin syringe (1 mL = 100 units)

Subcutaneous Injection Regimen

Vial

500 mg / 2.5 ml

Single dose

5u-25u=10 mg–50 mg

Frequency

first 7 days daily, then every other day

Time of administration

morning

Injections from 1st vial

10-12 injections

Vials per course

2-3 vials

for overweight, add +5 Units (10 mg)

Administration Rate

30–60 sec/0.1 ml

Rotate injection sites

abdomen, shoulder, thigh, buttock

Possible adverse reactions

Possible:

Erythema, itching, induration.

Systemic:

headache, dizziness, dyspepsia.

In case of severe reactions, discontinue therapy and provide symptomatic treatment.

Special instructions

Gradually titrate the dose.

Administer in the first half of the day, 1–1.5 hours after a meal.

In case of adverse reactions, adjust dose or temporarily discontinue.

Store opened vial at 2–8°C, use within one month.

Do not mix with other medications in the same syringe.

Storage conditions

Store at 2–8°C, out of reach of children and protected from light.

Do not freeze.

Shelf life

The shelf life of the NAD+ product is 24 months from the manufacturing date, provided it is stored at 2–8°C. Do not use after the expiration date indicated on the packaging.

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